5foe
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the C. elegans Protein O-fucosyltransferase 2 (CePOFUT2) double mutant (R298K-R299K) in complex with GDP and the human TSR1 from thrombospondin 1== | |
| - | + | <StructureSection load='5foe' size='340' side='right' caption='[[5foe]], [[Resolution|resolution]] 1.98Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5foe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FOE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FOE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5foe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5foe OCA], [http://pdbe.org/5foe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5foe RCSB], [http://www.ebi.ac.uk/pdbsum/5foe PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/OFUT2_CAEEL OFUT2_CAEEL]] Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13 (By similarity).<ref>PMID:15233996</ref> |
| - | [[ | + | == References == |
| - | [[ | + | <references/> |
| - | [[ | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| - | [[Category: | + | [[Category: Corzana, F]] |
| - | [[Category: Haltiwanger, R | + | [[Category: Haltiwanger, R S]] |
[[Category: Hernandez-Ruiz, C]] | [[Category: Hernandez-Ruiz, C]] | ||
[[Category: Hurtado-Guerrero, R]] | [[Category: Hurtado-Guerrero, R]] | ||
| + | [[Category: Jimenez-Oses, G]] | ||
| + | [[Category: Leonhard-Melief, C]] | ||
[[Category: Lira-Navarrete, E]] | [[Category: Lira-Navarrete, E]] | ||
[[Category: Lostao, A]] | [[Category: Lostao, A]] | ||
| - | [[Category: | + | [[Category: Pallares, M C]] |
| - | [[Category: | + | [[Category: Takeuchi, H]] |
| + | [[Category: Valero-Gonzalez, J]] | ||
| + | [[Category: Vasudevan, D]] | ||
| + | [[Category: Yruela, I]] | ||
| + | [[Category: Afm]] | ||
| + | [[Category: Fusion protein]] | ||
| + | [[Category: Glycosyltransferase]] | ||
| + | [[Category: Itc]] | ||
| + | [[Category: Molecular dynamic]] | ||
| + | [[Category: Pofut2]] | ||
| + | [[Category: Site-directed mutagenesis]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Tsr1]] | ||
| + | [[Category: Water]] | ||
Revision as of 02:37, 28 January 2016
Crystal structure of the C. elegans Protein O-fucosyltransferase 2 (CePOFUT2) double mutant (R298K-R299K) in complex with GDP and the human TSR1 from thrombospondin 1
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Categories: Corzana, F | Haltiwanger, R S | Hernandez-Ruiz, C | Hurtado-Guerrero, R | Jimenez-Oses, G | Leonhard-Melief, C | Lira-Navarrete, E | Lostao, A | Pallares, M C | Takeuchi, H | Valero-Gonzalez, J | Vasudevan, D | Yruela, I | Afm | Fusion protein | Glycosyltransferase | Itc | Molecular dynamic | Pofut2 | Site-directed mutagenesis | Transferase | Tsr1 | Water
