1c32

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|PDB= 1c32 |SIZE=350|CAPTION= <scene name='initialview01'>1c32</scene>
|PDB= 1c32 |SIZE=350|CAPTION= <scene name='initialview01'>1c32</scene>
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|SITE=
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|LIGAND= <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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|ACTIVITY=
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|GENE=
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|RELATEDENTRY=[[1qdf|1QDF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c32 OCA], [http://www.ebi.ac.uk/pdbsum/1c32 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c32 RCSB]</span>
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[[Category: thrombin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:19:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:13:29 2008''

Revision as of 16:13, 30 March 2008

Image:1c32.gif


PDB ID 1c32

Drag the structure with the mouse to rotate
Ligands: ,
Related: 1QDF


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE


Overview

Potassium can stabilize the formation of chair- or edge-type quadruplex DNA structures and appears to be the only naturally occurring cation that can do so. As quadruplex DNAs may be important in the structure of telomere, centromere, triplet repeat and other DNAs, information about the details of the potassium-quadruplex DNA interactions are of interest. The structures of the 1:1 and the fully saturated, 2:1, potassium-DNA complexes of d(GGTTGGTGTGGTTGG) have been determined using the combination of experimental NMR results and restrained molecular dynamics simulations. The refined structures have been used to model the interactions at the potassium binding sites. Comparison of the 1:1 and 2:1 potassium:DNA structures indicates how potassium binding can determine the folding pattern of the DNA. In each binding site potassium interacts with the carbonyl oxygens of both the loop thymine residues and the guanine residues of the adjacent quartet.

About this Structure

1C32 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA., Marathias VM, Bolton PH, Nucleic Acids Res. 2000 May 1;28(9):1969-77. PMID:10756199

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