Sandbox Reserved 1128

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Thioredoxin reductase (TrXR) is a ubiquitous enzyme which reduces the thioredoxin protein by a disulfide oxidoreductase activity. This enzyme belongs to the flavoprotein family which needs cofactors to catalyze the NADPH dependent reaction. NADPH cofactor allows electrons transmission during the reaction via FAD from enzyme to oxidized protein. The thioredoxin system is thus composed of thioredoxin reductase, NADPH and thioredoxin with the following reaction:
Thioredoxin reductase (TrXR) is a ubiquitous enzyme which reduces the thioredoxin protein by a disulfide oxidoreductase activity. This enzyme belongs to the flavoprotein family which needs cofactors to catalyze the NADPH dependent reaction. NADPH cofactor allows electrons transmission during the reaction via FAD from enzyme to oxidized protein. The thioredoxin system is thus composed of thioredoxin reductase, NADPH and thioredoxin with the following reaction:
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[[File:TrxR Reaction.jpg]]
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[[File:TrxR_reaction.jpg]]
TrxR1 belongs to one of the two forms of mammalian TrxR enzymes mostly present in cytosol contrary to TrxR2 which is only mitochondrial. TrxR1 is heterogeneous protein which is present in most tissues and she is specific of the small thioredoxin 1 protein (Trx1). Its capacity to reduce oxidized Trx1 is important to maintain the active site of Trx1. The redox activity of Trx1 reduced is the key of its biological activity. TrxR1 can thus regulate Trx1 activities by its NADPH dependent reduction specificity.
TrxR1 belongs to one of the two forms of mammalian TrxR enzymes mostly present in cytosol contrary to TrxR2 which is only mitochondrial. TrxR1 is heterogeneous protein which is present in most tissues and she is specific of the small thioredoxin 1 protein (Trx1). Its capacity to reduce oxidized Trx1 is important to maintain the active site of Trx1. The redox activity of Trx1 reduced is the key of its biological activity. TrxR1 can thus regulate Trx1 activities by its NADPH dependent reduction specificity.

Revision as of 12:37, 29 January 2016

This Sandbox is Reserved from 15/12/2015, through 15/06/2016 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1120 through Sandbox Reserved 1159.
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Human Thioredoxin Reductase 1

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