Dynactin
From Proteopedia
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== Function == | == Function == | ||
| - | '''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.<ref>PMID:1836789</ref> | + | '''Dynactin''' (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.<ref>PMID:1836789</ref> See also [[CAP-Gly domain]]. |
== Disease == | == Disease == | ||
Revision as of 08:03, 31 January 2016
Contents |
Function
Dynactin (DCTN) is a multi-subunit protein which modulates the binding of dynein to cell organelles which are to be transported along microtubules.[1] See also CAP-Gly domain.
Disease
Mutant dynactin was found in motor neuron disease.[2]
3D Structures of Dynactin
Updated on 31-January-2016
2coy - hDCTN subunit 1 CAP-Gly domain – human – NMR
3e2u – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1
2hkq, 2hl3, 1txq - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal
2hqh - hDCTN subunit 1 CAP-Gly domain + restin 2nd zinc finger domain
2hl5, 3tq7 - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal
2m02 - DCTN subunit 1 CAP-Gly domain – rat – NMR
3tv0 - hDCTN subunit 6
5aft – pDCTN subunits 2,3,5,6 + actin-related protein + actin + capping protein – pig – CryoEM
5afu – pDCTN subunits 2,3,5,6 + dynein tail + capping protein – CryoEM
References
- ↑ Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec;115(6):1639-50. PMID:1836789
- ↑ Puls I, Jonnakuty C, LaMonte BH, Holzbaur EL, Tokito M, Mann E, Floeter MK, Bidus K, Drayna D, Oh SJ, Brown RH Jr, Ludlow CL, Fischbeck KH. Mutant dynactin in motor neuron disease. Nat Genet. 2003 Apr;33(4):455-6. Epub 2003 Mar 10. PMID:12627231 doi:10.1038/ng1123
