Cruzain

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== Structural highlights ==
== Structural highlights ==
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<scene name='51/517378/Cv/2'>Cru catalytic triad is Cys-His-Asn</scene> ([[1me3]]).<ref>PMID:12467703</ref>
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<scene name='51/517378/Cv/2'>Cru catalytic triad is Cys-His-Asn</scene> and <scene name='51/517378/Cv/4'>whole binding site</scene> ([[1me3]]).<ref>PMID:12467703</ref>
</StructureSection>
</StructureSection>

Revision as of 08:49, 1 February 2016

Structure of cruzain catalytic domain complex with methylketone inhibitor (PDB entry 1me3)

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3D structures of cruzain

Updated on 01-February-2016

1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi
1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor
1ewp - Cru catalytic domain + MOR-Leu-HPQ

References

  1. ↑ Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure. 2000 Aug 15;8(8):831-40. PMID:10997902
  2. ↑ Huang L, Brinen LS, Ellman JA. Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain. Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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