3jcl

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m (Protected "3jcl" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer==
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<StructureSection load='3jcl' size='340' side='right' caption='[[3jcl]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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The entry 3jcl is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3jcl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JCL FirstGlance]. <br>
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Authors: Walls, A.C., Tortorici, M.A., Bosch, B.J., Frenz, B., Rottier, P.J.M., DiMaio, F., Rey, F.A., Veesler, D.
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jcl OCA], [http://pdbe.org/3jcl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jcl RCSB], [http://www.ebi.ac.uk/pdbsum/3jcl PDBsum]</span></td></tr>
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</table>
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Description: Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer
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== Function ==
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[[Category: Unreleased Structures]]
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[[http://www.uniprot.org/uniprot/SPIKE_CVMA5 SPIKE_CVMA5]] S1 attaches the virion to the cell membrane by interacting with murine CEACAM1, initiating the infection.<ref>PMID:16014947</ref> S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Presumably interacts with target cell lipid raft after cell attachment.<ref>PMID:16014947</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bosch, B J]]
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[[Category: DiMaio, F]]
[[Category: Frenz, B]]
[[Category: Frenz, B]]
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[[Category: Rottier, P.J.M]]
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[[Category: Rey, F A]]
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[[Category: Rottier, P J.M]]
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[[Category: Tortorici, M A]]
[[Category: Veesler, D]]
[[Category: Veesler, D]]
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[[Category: Tortorici, M.A]]
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[[Category: Walls, A C]]
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[[Category: Rey, F.A]]
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[[Category: Coronavirus]]
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[[Category: Dimaio, F]]
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[[Category: Peplomer]]
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[[Category: Bosch, B.J]]
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[[Category: Viral fusion protein]]
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[[Category: Walls, A.C]]
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[[Category: Viral protein]]
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[[Category: Viral spike]]

Revision as of 15:48, 3 February 2016

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

3jcl, resolution 4.00Å

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