4ww2
From Proteopedia
(Difference between revisions)
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- | ''' | + | ==Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8, Antigen-presenting glycoprotein CD1d, and Beta-2-microglobulin== |
- | + | <StructureSection load='4ww2' size='340' side='right' caption='[[4ww2]], [[Resolution|resolution]] 2.48Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[4ww2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WW2 FirstGlance]. <br> | |
- | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JLS:(15Z)-N-[(2S,3S,4R)-1-(ALPHA-D-GALACTOPYRANOSYLOXY)-3,4-DIHYDROXYOCTADECAN-2-YL]TETRACOS-15-ENAMIDE'>JLS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
- | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ww1|4ww1]]</td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ww2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ww2 OCA], [http://pdbe.org/4ww2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ww2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ww2 PDBsum]</span></td></tr> | |
- | [[ | + | </table> |
- | [ | + | == Disease == |
- | [ | + | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> |
- | + | == Function == | |
- | [[ | + | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref> |
- | [[ | + | == References == |
- | [[Category: | + | <references/> |
- | [[Category: | + | __TOC__ |
- | [[Category: | + | </StructureSection> |
+ | [[Category: Besra, G]] | ||
+ | [[Category: Gherardin, N A]] | ||
+ | [[Category: Godfrey, D I]] | ||
[[Category: Gras, S]] | [[Category: Gras, S]] | ||
- | [[Category: | + | [[Category: Howell, A R]] |
[[Category: Keshipeddy, S]] | [[Category: Keshipeddy, S]] | ||
- | [[Category: | + | [[Category: Lim, R T]] |
+ | [[Category: Nours, J Le]] | ||
[[Category: Pellicci, D]] | [[Category: Pellicci, D]] | ||
+ | [[Category: Praveena, T]] | ||
+ | [[Category: Richardson, S K]] | ||
+ | [[Category: Rossjohn, J]] | ||
+ | [[Category: Uldrich, A P]] | ||
+ | [[Category: Immune system]] | ||
+ | [[Category: Immunity]] | ||
+ | [[Category: Natural killer t cell]] |
Revision as of 15:49, 3 February 2016
Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8, Antigen-presenting glycoprotein CD1d, and Beta-2-microglobulin
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