4ww2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8, Antigen-presenting glycoprotein CD1d, and Beta-2-microglobulin==
-
 
+
<StructureSection load='4ww2' size='340' side='right' caption='[[4ww2]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
-
The entry 4ww2 is ON HOLD until May 12 2017
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4ww2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WW2 FirstGlance]. <br>
-
Authors: Le Nours, J., Praveena, T., Pellicci, D., Gherardin, N.A., Lim, R.T., Besra, G., Keshipeddy, S., Richardson, S.K., Howell, A.R., Gras, S., Godfrey, D.I., Rossjohn, J., Uldrich, A.P.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JLS:(15Z)-N-[(2S,3S,4R)-1-(ALPHA-D-GALACTOPYRANOSYLOXY)-3,4-DIHYDROXYOCTADECAN-2-YL]TETRACOS-15-ENAMIDE'>JLS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
 
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ww1|4ww1]]</td></tr>
-
Description:
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ww2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ww2 OCA], [http://pdbe.org/4ww2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ww2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ww2 PDBsum]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
-
[[Category: Le Nours, J]]
+
== Disease ==
-
[[Category: Uldrich, A.P]]
+
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
-
[[Category: Howell, A.R]]
+
== Function ==
-
[[Category: Lim, R.T]]
+
[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [[http://www.uniprot.org/uniprot/CD1D_HUMAN CD1D_HUMAN]] Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:17475845</ref>
-
[[Category: Richardson, S.K]]
+
== References ==
-
[[Category: Praveena, T]]
+
<references/>
-
[[Category: Rossjohn, J]]
+
__TOC__
-
[[Category: Gherardin, N.A]]
+
</StructureSection>
 +
[[Category: Besra, G]]
 +
[[Category: Gherardin, N A]]
 +
[[Category: Godfrey, D I]]
[[Category: Gras, S]]
[[Category: Gras, S]]
-
[[Category: Godfrey, D.I]]
+
[[Category: Howell, A R]]
[[Category: Keshipeddy, S]]
[[Category: Keshipeddy, S]]
-
[[Category: Besra, G]]
+
[[Category: Lim, R T]]
 +
[[Category: Nours, J Le]]
[[Category: Pellicci, D]]
[[Category: Pellicci, D]]
 +
[[Category: Praveena, T]]
 +
[[Category: Richardson, S K]]
 +
[[Category: Rossjohn, J]]
 +
[[Category: Uldrich, A P]]
 +
[[Category: Immune system]]
 +
[[Category: Immunity]]
 +
[[Category: Natural killer t cell]]

Revision as of 15:49, 3 February 2016

Crystal structure of human TCR Alpha Chain-TRAV21-TRAJ8, Beta Chain-TRBV7-8, Antigen-presenting glycoprotein CD1d, and Beta-2-microglobulin

4ww2, resolution 2.48Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools