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5hg6
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| - | ''' | + | ==The crystal structure of mouse TLR4/MD-2/lipid A complex== |
| - | + | <StructureSection load='5hg6' size='340' side='right' caption='[[5hg6]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hg6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HG6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HG6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=LP4:2-DEOXY-3-O-[(3R)-3-HYDROXYTETRADECANOYL]-2-{[(3R)-3-HYDROXYTETRADECANOYL]AMINO}-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSE'>LP4</scene>, <scene name='pdbligand=LP5:(R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL)+3-HYDROXYTETRADECANOATE'>LP5</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hg3|5hg3]], [[5hg4|5hg4]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hg6 OCA], [http://pdbe.org/5hg6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hg6 RCSB], [http://www.ebi.ac.uk/pdbsum/5hg6 PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Disease == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE]] Note=The protein is encoded by the Lps locus, an important susceptibility locus, influencing the propensity to develop a disseminated Gram-negative infection. |
| - | [[ | + | == Function == |
| - | [ | + | [[http://www.uniprot.org/uniprot/TLR4_MOUSE TLR4_MOUSE]] Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).<ref>PMID:10952994</ref> [[http://www.uniprot.org/uniprot/LY96_MOUSE LY96_MOUSE]] Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS (By similarity). |
| - | [[ | + | == References == |
| - | [[ | + | <references/> |
| - | [[ | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Berger, M]] | [[Category: Berger, M]] | ||
| - | [[Category: | + | [[Category: Beutler, B]] |
| + | [[Category: Boger, D L]] | ||
| + | [[Category: Choi, J H]] | ||
[[Category: Huang, H]] | [[Category: Huang, H]] | ||
| + | [[Category: Jones, B T]] | ||
| + | [[Category: Moresco, E M]] | ||
| + | [[Category: Morin, M D]] | ||
| + | [[Category: Shi, H]] | ||
[[Category: Su, L]] | [[Category: Su, L]] | ||
[[Category: Surakattula, M]] | [[Category: Surakattula, M]] | ||
| - | [[Category: | + | [[Category: Wang, K]] |
| - | [[Category: | + | [[Category: Wang, Y]] |
| - | [[Category: | + | [[Category: Whitby, L R]] |
| - | [[Category: | + | [[Category: Zhan, X]] |
| + | [[Category: Zhang, H]] | ||
| + | [[Category: Immune response]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Natural agonist]] | ||
| + | [[Category: Protein complex]] | ||
Revision as of 15:58, 3 February 2016
The crystal structure of mouse TLR4/MD-2/lipid A complex
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Categories: Berger, M | Beutler, B | Boger, D L | Choi, J H | Huang, H | Jones, B T | Moresco, E M | Morin, M D | Shi, H | Su, L | Surakattula, M | Wang, K | Wang, Y | Whitby, L R | Zhan, X | Zhang, H | Immune response | Immune system | Natural agonist | Protein complex
