This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1cd9
From Proteopedia
| Line 7: | Line 7: | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cd9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cd9 OCA], [http://www.ebi.ac.uk/pdbsum/1cd9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cd9 RCSB]</span> | ||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: Okamoto, T.]] | [[Category: Okamoto, T.]] | ||
[[Category: Ota, Y.]] | [[Category: Ota, Y.]] | ||
| - | [[Category: NAG]] | ||
[[Category: class1 cytokine]] | [[Category: class1 cytokine]] | ||
[[Category: hematopoietic receptor]] | [[Category: hematopoietic receptor]] | ||
[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:19:20 2008'' |
Revision as of 16:19, 30 March 2008
| |||||||
| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR
Overview
Granulocyte colony-stimulating factor (GCSF) is the principal growth factor regulating the maturation, proliferation and differentiation of the precursor cells of neutrophilic granulocytes and is used to treat neutropenia. GCSF is a member of the long-chain subtype of the class 1 cytokine superfamily, which includes growth hormone, erythropoietin, interleukin 6 and oncostatin M. Here we have determined the crystal structure of GCSF complexed to the BN-BC domains, the principal ligand-binding region of the GCSF receptor (GCSFR). The two receptor domains form a complex in a 2:2 ratio with the ligand, with a non-crystallographic pseudo-twofold axis through primarily the interdomain region and secondarily the BC domain. This structural view of a gp130-type receptor-ligand complex presents a new molecular basis for cytokine-receptor recognition.
About this Structure
1CD9 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
Reference
Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme., Aritomi M, Kunishima N, Okamoto T, Kuroki R, Ota Y, Morikawa K, Nature. 1999 Oct 14;401(6754):713-7. PMID:10537111
Page seeded by OCA on Sun Mar 30 19:19:20 2008
