DNA damage-binding protein
From Proteopedia
(Difference between revisions)
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| - | <StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 ( | + | <StructureSection load='3ei1' size='350' side='right' caption='Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code [[3ei1]]).' scene='54/541124/Cv/1'> |
== Function == | == Function == | ||
| - | '''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2.<ref>PMID:18593899</ref><br /> | + | '''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>. |
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| + | DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/3'>5PY and 64T</scene>, they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE. | ||
| + | <ref>PMID:18593899</ref><br /> | ||
== Disease == | == Disease == | ||
Revision as of 09:07, 7 February 2016
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3D Structures of DNA damage-binding protein
Updated on 07-February-2016
References
- ↑ Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapic-Otrin V. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. Cancer Res. 2008 Jul 1;68(13):5014-22. PMID:18593899 doi:68/13/5014
