DNA damage-binding protein
From Proteopedia
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'''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>. | '''DNA damage-binding protein''' (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. <scene name='54/541124/Cv/2'>DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2</scene>. | ||
| - | DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene>, they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> | + | DNA in this complex with DDB1 and DDB2 contains modified compounds <scene name='54/541124/Cv/5'>5PY and 64T</scene> (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.<ref>PMID:18593899</ref><br /> Water molecules shown as red spheres. |
== Disease == | == Disease == | ||
Revision as of 09:10, 7 February 2016
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3D Structures of DNA damage-binding protein
Updated on 07-February-2016
References
- ↑ Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapic-Otrin V. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. Cancer Res. 2008 Jul 1;68(13):5014-22. PMID:18593899 doi:68/13/5014
