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3hy4
From Proteopedia
(Difference between revisions)
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<StructureSection load='3hy4' size='340' side='right' caption='[[3hy4]], [[Resolution|resolution]] 2.79Å' scene=''> | <StructureSection load='3hy4' size='340' side='right' caption='[[3hy4]], [[Resolution|resolution]] 2.79Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3hy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3hy4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HY4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N5G:N-({TRANS-4-[({(2R,4R,4AS,6S,8AS)-2-AMINO-4-HYDROXY-5-[(PHOSPHONOOXY)METHYL]DECAHYDROPTERIDIN-6-YL}METHYL)AMINO]CYCLOHEXYL}CARBONYL)-L-GLUTAMIC+ACID'>N5G</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=N5G:N-({TRANS-4-[({(2R,4R,4AS,6S,8AS)-2-AMINO-4-HYDROXY-5-[(PHOSPHONOOXY)METHYL]DECAHYDROPTERIDIN-6-YL}METHYL)AMINO]CYCLOHEXYL}CARBONYL)-L-GLUTAMIC+ACID'>N5G</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hxt|3hxt]], [[3hy3|3hy3]], [[3hy6|3hy6]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hxt|3hxt]], [[3hy3|3hy3]], [[3hy6|3hy6]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTHFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTHFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-formyltetrahydrofolate_cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.2 6.3.3.2] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-formyltetrahydrofolate_cyclo-ligase 5-formyltetrahydrofolate cyclo-ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.3.2 6.3.3.2] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hy4 RCSB], [http://www.ebi.ac.uk/pdbsum/3hy4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hy4 OCA], [http://pdbe.org/3hy4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hy4 RCSB], [http://www.ebi.ac.uk/pdbsum/3hy4 PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hy4 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3hy4" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: 5-formyltetrahydrofolate cyclo-ligase]] | [[Category: 5-formyltetrahydrofolate cyclo-ligase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Cheng, C]] | [[Category: Cheng, C]] | ||
[[Category: Li, Y]] | [[Category: Li, Y]] | ||
Revision as of 09:36, 7 February 2016
Structure of human MTHFS with N5-iminium phosphate
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Categories: 5-formyltetrahydrofolate cyclo-ligase | Human | Cheng, C | Li, Y | Liu, Z J | Shaw, N | Song, G | Wu, D | Antifolate | Atp-binding | Cancer | Folate-binding | Ligase | Magnesium | N5-iminium phosphate | Nucleotide-binding
