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1cos
From Proteopedia
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|PDB= 1cos |SIZE=350|CAPTION= <scene name='initialview01'>1cos</scene>, resolution 2.1Å | |PDB= 1cos |SIZE=350|CAPTION= <scene name='initialview01'>1cos</scene>, resolution 2.1Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> | + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cos OCA], [http://www.ebi.ac.uk/pdbsum/1cos PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cos RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 31: | ||
[[Category: Lovejoy, B.]] | [[Category: Lovejoy, B.]] | ||
[[Category: Mcrorie, D K.]] | [[Category: Mcrorie, D K.]] | ||
| - | [[Category: ACE]] | ||
| - | [[Category: NH2]] | ||
[[Category: alpha-helical bundle]] | [[Category: alpha-helical bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:25:38 2008'' |
Revision as of 16:25, 30 March 2008
| |||||||
| , resolution 2.1Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE
Overview
The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute.
About this Structure
1COS is a Protein complex structure of sequences from [1]. The following page contains interesting information on the relation of 1COS with [Designer Proteins]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a synthetic triple-stranded alpha-helical bundle., Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D, Science. 1993 Feb 26;259(5099):1288-93. PMID:8446897
Page seeded by OCA on Sun Mar 30 19:25:38 2008
