1o7p
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1O7P is a | + | 1O7P is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida] with SO4, FE, EDO, NDH and FES as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Naphthalene_1,2-dioxygenase Naphthalene 1,2-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.12.12 1.14.12.12] Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1O7P OCA]. |
==Reference== | ==Reference== | ||
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[[Category: oxidoreductase]] | [[Category: oxidoreductase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:12:15 2007'' |
Revision as of 13:06, 5 November 2007
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NAPHTHALENE 1,2-DIOXYGENASE, PRODUCT COMPLEX
Overview
Binding of oxygen to iron is exploited in several biological and chemical, processes. Although computational and spectroscopic results have suggested, side-on binding, only end-on binding of oxygen to iron has been observed, in crystal structures. We have determined structures of naphthalene, dioxygenase that show a molecular oxygen species bound to the mononuclear, iron in a side-on fashion. In a complex with substrate and dioxygen, the, dioxygen molecule is lined up for an attack on the double bond of the, aromatic substrate. The structures reported here provide the basis for a, reaction mechanism and for the high stereospecificity of the reaction, catalyzed by naphthalene dioxygenase.
About this Structure
1O7P is a Protein complex structure of sequences from Pseudomonas putida with SO4, FE, EDO, NDH and FES as ligands. Active as Naphthalene 1,2-dioxygenase, with EC number 1.14.12.12 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Crystal structure of naphthalene dioxygenase: side-on binding of dioxygen to iron., Karlsson A, Parales JV, Parales RE, Gibson DT, Eklund H, Ramaswamy S, Science. 2003 Feb 14;299(5609):1039-42. PMID:12586937
Page seeded by OCA on Mon Nov 5 15:12:15 2007
Categories: Naphthalene 1,2-dioxygenase | Protein complex | Pseudomonas putida | Eklund, H. | Gibson, D.T. | Karlsson, A. | Parales, J.V. | Parales, R.E. | Ramaswamy, S. | EDO | FE | FES | NDH | SO4 | Aromatic hydrocarbon catabolism oxidoreductase | Enzyme-substrate complex | Iron-sulfur | Non-heme iron dioxygenase | Oxidoreductase
