1cun
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= CHICKEN BRAIN MRNA FOR SPECTRIN ALPHA-CHAIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]) | |GENE= CHICKEN BRAIN MRNA FOR SPECTRIN ALPHA-CHAIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cun OCA], [http://www.ebi.ac.uk/pdbsum/1cun PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cun RCSB]</span> | ||
}} | }} | ||
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[[Category: two repeats of spectrin]] | [[Category: two repeats of spectrin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:28:52 2008'' |
Revision as of 16:28, 30 March 2008
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| , resolution 2.00Å | |||||||
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| Gene: | CHICKEN BRAIN MRNA FOR SPECTRIN ALPHA-CHAIN (Gallus gallus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF REPEATS 16 AND 17 OF CHICKEN BRAIN ALPHA SPECTRIN
Overview
Spectrin is a vital component of the cytoskeleton, conferring flexibility on cells and providing a scaffold for a variety of proteins. It is composed of tandem, antiparallel coiled-coil repeats. We report four related crystal structures at 1.45 A, 2.0 A, 3.1 A, and 4.0 A resolution of two connected repeats of chicken brain alpha-spectrin. In all of the structures, the linker region between adjacent units is alpha-helical without breaks, kinks, or obvious boundaries. Two features observed in the structures are (1) conformational rearrangement in one repeat, resulting in movement of the position of a loop, and (2) varying degrees of bending at the linker region. These features form the basis of two different models of flexibility: a conformational rearrangement and a bending model. These models provide novel atomic details of spectrin flexibility.
About this Structure
1CUN is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
Structures of two repeats of spectrin suggest models of flexibility., Grum VL, Li D, MacDonald RI, Mondragon A, Cell. 1999 Aug 20;98(4):523-35. PMID:10481916
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