1cwl
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1cwl |SIZE=350|CAPTION= <scene name='initialview01'>1cwl</scene>, resolution 1.80Å | |PDB= 1cwl |SIZE=350|CAPTION= <scene name='initialview01'>1cwl</scene>, resolution 1.80Å | ||
|SITE= <scene name='pdbsite=BIN:Cyclosporin+Binding+Site'>BIN</scene> | |SITE= <scene name='pdbsite=BIN:Cyclosporin+Binding+Site'>BIN</scene> | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MHL:N-METHYL-4-HYDROXY-LEUCINE'>MHL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span> |
|GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cwl OCA], [http://www.ebi.ac.uk/pdbsum/1cwl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cwl RCSB]</span> | ||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: complex (isomerase/immunosuppressant)]] | [[Category: complex (isomerase/immunosuppressant)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:29:58 2008'' |
Revision as of 16:30, 30 March 2008
| |||||||
| , resolution 1.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , , , , , | ||||||
| Gene: | CYCLOPHILIN (Homo sapiens) | ||||||
| Activity: | Peptidylprolyl isomerase, with EC number 5.2.1.8 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN CYCLOPHILIN A COMPLEXED WITH 4 4-HYDROXY-MELEU CYCLOSPORIN
Overview
Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.
About this Structure
1CWL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216
Page seeded by OCA on Sun Mar 30 19:29:58 2008
