1d32
From Proteopedia
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|PDB= 1d32 |SIZE=350|CAPTION= <scene name='initialview01'>1d32</scene>, resolution 1.700Å | |PDB= 1d32 |SIZE=350|CAPTION= <scene name='initialview01'>1d32</scene>, resolution 1.700Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=DIT:DITERCALINIUM'>DIT</scene> | + | |LIGAND= <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DIT:DITERCALINIUM'>DIT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d32 OCA], [http://www.ebi.ac.uk/pdbsum/1d32 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d32 RCSB]</span> | ||
}} | }} | ||
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[[Category: Rich, A.]] | [[Category: Rich, A.]] | ||
[[Category: Williams, L D.]] | [[Category: Williams, L D.]] | ||
| - | [[Category: DIT]] | ||
[[Category: complexed with drug]] | [[Category: complexed with drug]] | ||
[[Category: double helix]] | [[Category: double helix]] | ||
[[Category: right handed dna]] | [[Category: right handed dna]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:33:40 2008'' |
Revision as of 16:33, 30 March 2008
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| , resolution 1.700Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX
Overview
Ditercalinium is a synthetic anticancer drug that binds to DNA by bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray crystallography, we have determined, to 1.7 A resolution, the three-dimensional structure of a complex of ditercalinium bound to the double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with ditercalinium is kinked (by 15 degrees) and severely unwound (by 36 degrees) with exceptionally wide major and minor grooves. Recognition of the DNA-ditercalinium complex by uvrABC in prokaryotes, and by mitochondrial DNA repair systems in eukaryotes, might be related to drug-induced distortion of the DNA helix.
About this Structure
1D32 is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex., Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A, Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:2006181
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