1d5v
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5v OCA], [http://www.ebi.ac.uk/pdbsum/1d5v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d5v RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif. | Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif. | ||
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| - | ==Disease== | ||
| - | Known diseases associated with this structure: Lymphedema and ptosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Lymphedema, hereditary II OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Lymphedema-distichiasis syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Lymphedema-distichiasis syndrome with renal disease and diabetes mellitus OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]], Yellow nail syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602402 602402]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: winged helix]] | [[Category: winged helix]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:35:12 2008'' |
Revision as of 16:35, 30 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)
Overview
Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif.
About this Structure
1D5V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11., van Dongen MJ, Cederberg A, Carlsson P, Enerback S, Wikstrom M, J Mol Biol. 2000 Feb 18;296(2):351-9. PMID:10669593
Page seeded by OCA on Sun Mar 30 19:35:12 2008
