2w7x
From Proteopedia
(Difference between revisions)
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<StructureSection load='2w7x' size='340' side='right' caption='[[2w7x]], [[Resolution|resolution]] 2.07Å' scene=''> | <StructureSection load='2w7x' size='340' side='right' caption='[[2w7x]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2w7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2w7x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2W7X FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D1A:N-[4-[(E)-N-CARBAMIMIDAMIDO-C-METHYL-CARBONIMIDOYL]PHENYL]-7-NITRO-1H-INDOLE-2-CARBOXAMIDE'>D1A</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D1A:N-[4-[(E)-N-CARBAMIMIDAMIDO-C-METHYL-CARBONIMIDOYL]PHENYL]-7-NITRO-1H-INDOLE-2-CARBOXAMIDE'>D1A</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cn8|2cn8]], [[2w0j|2w0j]], [[1gxc|1gxc]], [[2cn5|2cn5]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cn8|2cn8]], [[2w0j|2w0j]], [[1gxc|1gxc]], [[2cn5|2cn5]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2w7x RCSB], [http://www.ebi.ac.uk/pdbsum/2w7x PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2w7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w7x OCA], [http://pdbe.org/2w7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2w7x RCSB], [http://www.ebi.ac.uk/pdbsum/2w7x PDBsum]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w7x ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2w7x" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Caplen, N J]] | [[Category: Caplen, N J]] | ||
Revision as of 21:56, 7 February 2016
CELLULAR INHIBITION OF CHECKPOINT KINASE 2 AND POTENTIATION OF CYTOTOXIC DRUGS BY NOVEL CHK2 INHIBITOR PV1019
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Categories: Human | Non-specific serine/threonine protein kinase | Caplen, N J | Caredellina, J H | Connelly, J | Jobson, A G | Kondapaka, S | Llamas, J | Lorenzi, P L | Lountos, G T | Monks, A | Onda, A | Pommier, Y | Self, C | Shoemaker, R H | Tropea, J E | Waugh, D S | Zhang, G | Atp-binding | Cell cycle | Chk2 inhibitor | Co-crystal structure | Disease mutation | Kinase | Li-fraumeni syndrome | Magnesium | Metal-binding | Nucleotide-binding | Nucleus | Phosphoprotein | Potentiation | Proto-oncogene | Serine/threonine-protein kinase | Transferase
