1d9k
From Proteopedia
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|PDB= 1d9k |SIZE=350|CAPTION= <scene name='initialview01'>1d9k</scene>, resolution 3.2Å | |PDB= 1d9k |SIZE=350|CAPTION= <scene name='initialview01'>1d9k</scene>, resolution 3.2Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> | + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d9k OCA], [http://www.ebi.ac.uk/pdbsum/1d9k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d9k RCSB]</span> | ||
}} | }} | ||
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[[Category: Xiong, Y.]] | [[Category: Xiong, Y.]] | ||
[[Category: Zhang, R.]] | [[Category: Zhang, R.]] | ||
| - | [[Category: NDG]] | ||
[[Category: d10]] | [[Category: d10]] | ||
[[Category: i-ak]] | [[Category: i-ak]] | ||
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[[Category: t-cell receptor]] | [[Category: t-cell receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:37:14 2008'' |
Revision as of 16:37, 30 March 2008
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| , resolution 3.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA
Overview
The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign peptide antigen, and the I-Ak self major histocompatibility complex (MHC) class II molecule is reported at 3.2 angstrom resolution. The D10 TCR is oriented in an orthogonal mode relative to its peptide-MHC (pMHC) ligand, necessitated by the amino-terminal extension of peptide residues projecting from the MHC class II antigen-binding groove as part of a mini beta sheet. Consequently, the disposition of D10 complementarity-determining region loops is altered relative to that of most pMHCI-specific TCRs; the latter TCRs assume a diagonal orientation, although with substantial variability. Peptide recognition, which involves P-1 to P8 residues, is dominated by the Valpha domain, which also binds to the class II MHC beta1 helix. That docking is limited to one segment of MHC-bound peptide offers an explanation for epitope recognition and altered peptide ligand effects, suggests a structural basis for alloreactivity, and illustrates how bacterial superantigens can span the TCR-pMHCII surface.
About this Structure
1D9K is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
The crystal structure of a T cell receptor in complex with peptide and MHC class II., Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, Hussey RE, Smolyar A, Hare B, Zhang R, Joachimiak A, Chang HC, Wagner G, Wang J, Science. 1999 Dec 3;286(5446):1913-21. PMID:10583947
Page seeded by OCA on Sun Mar 30 19:37:14 2008
Categories: Mus musculus | Protein complex | Chang, H C. | Hare, B. | Hussey, R E. | Joachimiak, A. | Kern, P. | Liu, J H. | Reinherz, E L. | Smolyar, A. | Tan, K. | Tang, L. | Wagner, G. | Wang, J-H. | Xiong, Y. | Zhang, R. | D10 | I-ak | Mhc class ii | T-cell receptor
