1dgp
From Proteopedia
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|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=FOH:FARNESOL'>FOH</scene> | |LIGAND= <scene name='pdbligand=FOH:FARNESOL'>FOH</scene> | ||
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Aristolochene_synthase Aristolochene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.9 4.2.3.9] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aristolochene_synthase Aristolochene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.9 4.2.3.9] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1di1|1DI1]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgp OCA], [http://www.ebi.ac.uk/pdbsum/1dgp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dgp RCSB]</span> | ||
}} | }} | ||
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[[Category: Christianson, D W.]] | [[Category: Christianson, D W.]] | ||
[[Category: Kang, I.]] | [[Category: Kang, I.]] | ||
| - | [[Category: FOH]] | ||
[[Category: isoprenoid biosynthesis]] | [[Category: isoprenoid biosynthesis]] | ||
[[Category: sesquiterpene cyclase]] | [[Category: sesquiterpene cyclase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:41:25 2008'' |
Revision as of 16:41, 30 March 2008
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| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Aristolochene synthase, with EC number 4.2.3.9 | ||||||
| Related: | 1DI1
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
ARISTOLOCHENE SYNTHASE FARNESOL COMPLEX
Overview
The 2.5-A resolution crystal structure of recombinant aristolochene synthase from the blue cheese mold, Penicillium roqueforti, is the first of a fungal terpenoid cyclase. The structure of the enzyme reveals active site features that participate in the cyclization of the universal sesquiterpene cyclase substrate, farnesyl diphosphate, to form the bicyclic hydrocarbon aristolochene. Metal-triggered carbocation formation initiates the cyclization cascade, which proceeds through multiple complex intermediates to yield one exclusive structural and stereochemical isomer of aristolochene. Structural homology of this fungal cyclase with plant and bacterial terpenoid cyclases, despite minimal amino acid sequence identity, suggests divergence from a common, primordial ancestor in the evolution of terpene biosynthesis.
About this Structure
1DGP is a Single protein structure of sequence from Penicillium roqueforti. Full crystallographic information is available from OCA.
Reference
Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti., Caruthers JM, Kang I, Rynkiewicz MJ, Cane DE, Christianson DW, J Biol Chem. 2000 Aug 18;275(33):25533-9. PMID:10825154
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