1dlz
From Proteopedia
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|PDB= 1dlz |SIZE=350|CAPTION= <scene name='initialview01'>1dlz</scene> | |PDB= 1dlz |SIZE=350|CAPTION= <scene name='initialview01'>1dlz</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACE:ACETYL GROUP'>ACE</scene> | + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1joh|1JOH]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dlz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlz OCA], [http://www.ebi.ac.uk/pdbsum/1dlz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1dlz RCSB]</span> | ||
}} | }} | ||
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[[Category: Shenkarev, Z O.]] | [[Category: Shenkarev, Z O.]] | ||
[[Category: Tagaev, A A.]] | [[Category: Tagaev, A A.]] | ||
| - | [[Category: ACE]] | ||
[[Category: antibiotic]] | [[Category: antibiotic]] | ||
[[Category: bent helix]] | [[Category: bent helix]] | ||
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[[Category: zervamicin]] | [[Category: zervamicin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:44:09 2008'' |
Revision as of 16:44, 30 March 2008
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| Ligands: | , , , , | ||||||
| Related: | 1JOH
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SOLUTION STRUCTURE OF THE CHANNEL-FORMER ZERVAMICIN IIB (PEPTAIBOL ANTIBIOTIC)
Overview
Spatial structure of the membrane channel-forming hexadecapeptide, zervamicin IIB, was studied by NMR spectroscopy in mixed solvents of different polarity ranging from CDCl3/CD3OH (9:1, v/v) to CD3OH/H2O (1:1, v/v). The results show that in all solvents used the peptide has a very similar structure that is a bent amphiphilic helix with a mean backbone root mean square deviation (rmsd) value of ca. 0.3 A. Side chains of Trp1, Ile2, Gln3, Ile5 and Thr6 are mobile. The results are discussed in relation to the validity of the obtained structure to serve as a building block of zervamicin IIB ion channels.
About this Structure
1DLZ is a Protein complex structure of sequences from Emericellopsis salmosynnemata. Full crystallographic information is available from OCA.
Reference
NMR structure of the channel-former zervamicin IIB in isotropic solvents., Balashova TA, Shenkarev ZO, Tagaev AA, Ovchinnikova TV, Raap J, Arseniev AS, FEBS Lett. 2000 Jan 28;466(2-3):333-6. PMID:10682854
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