Dynactin

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<StructureSection load='2hl5' size='350' side='right' scene='' caption='Dynactin subunit 1 CAP-Gly domain (pink and yellow) complex with protein linker (grey and green) and chloride ion [[2hl5]]'>
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<StructureSection load='2hl5' size='350' side='right' scene='44/444636/Cv/1' caption='Dynactin subunit 1 CAP-Gly domain (magenta and yellow) complex with the C-terminal domain of human EB1 (cyan and green) and chloride ion [[2hl5]]'>
== Function ==
== Function ==
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Mutant dynactin was found in motor neuron disease.<ref>PMID:12627231</ref>
Mutant dynactin was found in motor neuron disease.<ref>PMID:12627231</ref>
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== Structural highlights ==
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<scene name='44/444636/Cv/3'>Dynactin subunit 1 CAP-Gly domain with the C-terminal domain of human EB1</scene> ([[2hl5]]).
</StructureSection>
</StructureSection>
== 3D Structures of Dynactin ==
== 3D Structures of Dynactin ==

Revision as of 08:14, 8 February 2016

Dynactin subunit 1 CAP-Gly domain (magenta and yellow) complex with the C-terminal domain of human EB1 (cyan and green) and chloride ion 2hl5

Drag the structure with the mouse to rotate

3D Structures of Dynactin

Updated on 08-February-2016

2coy - hDCTN subunit 1 CAP-Gly domain – human – NMR
3e2u – hDCTN subunit 1 CAP-Gly domain + CAP-Gly domain-containing protein linker 1
2hkq, 2hl3, 1txq - hDCTN subunit 1 CAP-Gly domain + microtubule-associated protein C-terminal
2hqh - hDCTN subunit 1 CAP-Gly domain + restin 2nd zinc finger domain
2hl5, 3tq7 - hDCTN subunit 1 CAP-Gly domain (mutant) + microtubule-associated protein C-terminal
2m02 - DCTN subunit 1 CAP-Gly domain – rat – NMR
3tv0 - hDCTN subunit 6
5aft – pDCTN subunits 2,3,5,6 + actin-related protein + actin + capping protein – pig – CryoEM
5afu – pDCTN subunits 2,3,5,6 + dynein tail + capping protein – CryoEM

References

  1. ↑ Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol. 1991 Dec;115(6):1639-50. PMID:1836789
  2. ↑ Puls I, Jonnakuty C, LaMonte BH, Holzbaur EL, Tokito M, Mann E, Floeter MK, Bidus K, Drayna D, Oh SJ, Brown RH Jr, Ludlow CL, Fischbeck KH. Mutant dynactin in motor neuron disease. Nat Genet. 2003 Apr;33(4):455-6. Epub 2003 Mar 10. PMID:12627231 doi:10.1038/ng1123

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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