1e07
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e07 OCA], [http://www.ebi.ac.uk/pdbsum/1e07 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e07 RCSB]</span> | ||
}} | }} | ||
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[[Category: tumour marker]] | [[Category: tumour marker]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:52:22 2008'' |
Revision as of 16:52, 30 March 2008
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THEORETICAL MODEL OF HUMAN CARCINOEMBRYONIC ANTIGEN BY HOMOLOGY MODELLING AND CURVE-FITTING TO EXPERIMENTAL SOLUTION SCATTERING DATA
Overview
MFE23 is a single chain Fv antibody that has a high affinity for carcinoembryonic antigen (CEA). A full homology model for CEA based on V-type, I-type and C2-type immunoglobulin folds, 28 oligosaccharides and the interdomain angle of CD2 was validated using solution scattering data. The superimposition of the intermolecular contacts observed in our recent crystal structure of MFE23 with the N-terminal domain of CEA permitted the MFE23-CEA complex to be modelled. Good surface and electrostatic complementarity and carbohydrate-unhindered access of MFE23 with the indentation between the first two CEA domains was observed. The model is supported by biochemical data and provides insight on the high affinity of MFE23 for CEA.
About this Structure
1E07 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23., Boehm MK, Perkins SJ, FEBS Lett. 2000 Jun 9;475(1):11-6. PMID:10854848
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