1e31
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1e31 |SIZE=350|CAPTION= <scene name='initialview01'>1e31</scene>, resolution 2.71Å | |PDB= 1e31 |SIZE=350|CAPTION= <scene name='initialview01'>1e31</scene>, resolution 2.71Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e31 OCA], [http://www.ebi.ac.uk/pdbsum/1e31 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e31 RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Margolis, R.]] | [[Category: Margolis, R.]] | ||
[[Category: Skoufias, D.]] | [[Category: Skoufias, D.]] | ||
| - | [[Category: CO]] | ||
| - | [[Category: ZN]] | ||
[[Category: apotosis]] | [[Category: apotosis]] | ||
[[Category: iap]] | [[Category: iap]] | ||
[[Category: zinc finger]] | [[Category: zinc finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:54:03 2008'' |
Revision as of 16:54, 30 March 2008
| |||||||
| , resolution 2.71Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SURVIVIN DIMER H. SAPIENS
Overview
Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions.
About this Structure
1E31 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions., Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL, Mol Cell. 2000 Jul;6(1):183-9. PMID:10949039
Page seeded by OCA on Sun Mar 30 19:54:03 2008
