1e96
From Proteopedia
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|PDB= 1e96 |SIZE=350|CAPTION= <scene name='initialview01'>1e96</scene>, resolution 2.4Å | |PDB= 1e96 |SIZE=350|CAPTION= <scene name='initialview01'>1e96</scene>, resolution 2.4Å | ||
|SITE= <scene name='pdbsite=GTP:Gtp+Binding+Site+For+Chain+A+Residue+200'>GTP</scene> | |SITE= <scene name='pdbsite=GTP:Gtp+Binding+Site+For+Chain+A+Residue+200'>GTP</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e96 OCA], [http://www.ebi.ac.uk/pdbsum/1e96 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1e96 RCSB]</span> | ||
}} | }} | ||
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==Overview== | ==Overview== | ||
p67phox is an essential part of the NADPH oxidase, a multiprotein enzyme complex that produces superoxide ions in response to microbial infection. Binding of the small GTPase Rac to p67phox is a key step in the assembly of the active enzyme complex. The structure of Rac.GTP bound to the N-terminal TPR (tetratricopeptide repeat) domain of p67phox reveals a novel mode of Rho family/effector interaction and explains the basis of GTPase specificity. Complex formation is largely mediated by an insertion between two TPR motifs, suggesting an unsuspected versatility of TPR domains in target recognition and in their more general role as scaffolds for the assembly of multiprotein complexes. | p67phox is an essential part of the NADPH oxidase, a multiprotein enzyme complex that produces superoxide ions in response to microbial infection. Binding of the small GTPase Rac to p67phox is a key step in the assembly of the active enzyme complex. The structure of Rac.GTP bound to the N-terminal TPR (tetratricopeptide repeat) domain of p67phox reveals a novel mode of Rho family/effector interaction and explains the basis of GTPase specificity. Complex formation is largely mediated by an insertion between two TPR motifs, suggesting an unsuspected versatility of TPR domains in target recognition and in their more general role as scaffolds for the assembly of multiprotein complexes. | ||
| - | |||
| - | ==Disease== | ||
| - | Known disease associated with this structure: Chronic granulomatous disease due to deficiency of NCF-2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608515 608515]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Smith, S J.M.]] | [[Category: Smith, S J.M.]] | ||
[[Category: Walker, P A.]] | [[Category: Walker, P A.]] | ||
| - | [[Category: GTP]] | ||
| - | [[Category: MG]] | ||
[[Category: gtpase]] | [[Category: gtpase]] | ||
[[Category: nadph oxidase]] | [[Category: nadph oxidase]] | ||
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[[Category: tpr motif]] | [[Category: tpr motif]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:57:53 2008'' |
Revision as of 16:57, 30 March 2008
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| , resolution 2.4Å | |||||||
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| Sites: | |||||||
| Ligands: | , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF THE RAC/P67PHOX COMPLEX
Overview
p67phox is an essential part of the NADPH oxidase, a multiprotein enzyme complex that produces superoxide ions in response to microbial infection. Binding of the small GTPase Rac to p67phox is a key step in the assembly of the active enzyme complex. The structure of Rac.GTP bound to the N-terminal TPR (tetratricopeptide repeat) domain of p67phox reveals a novel mode of Rho family/effector interaction and explains the basis of GTPase specificity. Complex formation is largely mediated by an insertion between two TPR motifs, suggesting an unsuspected versatility of TPR domains in target recognition and in their more general role as scaffolds for the assembly of multiprotein complexes.
About this Structure
1E96 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the TPR domain of p67phox in complex with Rac.GTP., Lapouge K, Smith SJ, Walker PA, Gamblin SJ, Smerdon SJ, Rittinger K, Mol Cell. 2000 Oct;6(4):899-907. PMID:11090627
Page seeded by OCA on Sun Mar 30 19:57:53 2008
