1epf
From Proteopedia
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|PDB= 1epf |SIZE=350|CAPTION= <scene name='initialview01'>1epf</scene>, resolution 1.85Å | |PDB= 1epf |SIZE=350|CAPTION= <scene name='initialview01'>1epf</scene>, resolution 1.85Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1epf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1epf OCA], [http://www.ebi.ac.uk/pdbsum/1epf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1epf RCSB]</span> | ||
}} | }} | ||
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[[Category: Larsen, I K.]] | [[Category: Larsen, I K.]] | ||
[[Category: Rasmussen, H.]] | [[Category: Rasmussen, H.]] | ||
| - | [[Category: CA]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
[[Category: immunoglobulin fold]] | [[Category: immunoglobulin fold]] | ||
[[Category: ncam]] | [[Category: ncam]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:07:12 2008'' |
Revision as of 17:07, 30 March 2008
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| , resolution 1.85Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)
Overview
The neural cell adhesion molecule NCAM, a member of the immunoglobulin superfamily, mediates cell-cell recognition and adhesion via a homophilic interaction. NCAM plays a key role during development and regeneration of the nervous system and is involved in synaptic plasticity associated with memory and learning. The 1.85 A crystal structure of the two N-terminal extracellular domains of NCAM reported here provides a structural basis for the homophilic interaction. The molecular packing of the two-domain structure reveals a cross shaped antiparallel dimer, and provides fundamental insight into trans-cellular recognition mediated by NCAM.
About this Structure
1EPF is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structural basis of cell-cell adhesion by NCAM., Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Larsen IK, Nat Struct Biol. 2000 May;7(5):389-93. PMID:10802736
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