3jrq

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<StructureSection load='3jrq' size='340' side='right' caption='[[3jrq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3jrq' size='340' side='right' caption='[[3jrq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3jrq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JRQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3jrq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JRQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JRQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A8S:(2Z,4E)-5-[(1S)-1-HYDROXY-2,6,6-TRIMETHYL-4-OXOCYCLOHEX-2-EN-1-YL]-3-METHYLPENTA-2,4-DIENOIC+ACID'>A8S</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jrs|3jrs]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jrs|3jrs]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jrq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jrq RCSB], [http://www.ebi.ac.uk/pdbsum/3jrq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jrq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jrq OCA], [http://pdbe.org/3jrq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jrq RCSB], [http://www.ebi.ac.uk/pdbsum/3jrq PDBsum]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/P2C56_ARATH P2C56_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), drought-induced resistance and rhizogenesis, response to glucose, high light stress, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as the actin reorganization in guard cells in response to ABA. Involved in the resistance to the bacterial pathogen Pseudomonas syringae pv. tomato. Controls negatively fibrillin expression that is involved in mediating ABA-induced photoprotection. May be involved in ABA content regulation. Plays a role in the Pro accumulation in response to reduced water availability (low water potential). Required for the ABA negative regulation of the ethylene-induced hyponastic growth. Involved in acquired thermotolerance of root growth and seedling survival. Activates/represses SRK2E/OST1 in response to ABA-dependent stimuli, especially in stomata closure regulation involving SLAC1.<ref>PMID:12228349</ref> <ref>PMID:1834244</ref> <ref>PMID:16652949</ref> <ref>PMID:8492808</ref> <ref>PMID:12232276</ref> <ref>PMID:12232124</ref> <ref>PMID:7568166</ref> <ref>PMID:12228349</ref> <ref>PMID:8898906</ref> <ref>PMID:8771791</ref> <ref>PMID:9108297</ref> <ref>PMID:9090884</ref> <ref>PMID:9165752</ref> <ref>PMID:9161030</ref> <ref>PMID:9263461</ref> <ref>PMID:9351242</ref> <ref>PMID:9276963</ref> <ref>PMID:9448270</ref> <ref>PMID:10645425</ref> <ref>PMID:10488243</ref> <ref>PMID:10521520</ref> <ref>PMID:10950871</ref> <ref>PMID:10872217</ref> <ref>PMID:11707572</ref> <ref>PMID:11208021</ref> <ref>PMID:11587514</ref> <ref>PMID:11289613</ref> <ref>PMID:11701885</ref> <ref>PMID:12194854</ref> <ref>PMID:12065416</ref> <ref>PMID:12432076</ref> <ref>PMID:12047634</ref> <ref>PMID:12713537</ref> <ref>PMID:14576281</ref> <ref>PMID:14596925</ref> <ref>PMID:12609042</ref> <ref>PMID:15144382</ref> <ref>PMID:15197253</ref> <ref>PMID:15618419</ref> <ref>PMID:15923322</ref> <ref>PMID:16365038</ref> <ref>PMID:16339784</ref> <ref>PMID:16571665</ref> <ref>PMID:16798945</ref> <ref>PMID:16614222</ref> <ref>PMID:17304219</ref> <ref>PMID:17158582</ref> <ref>PMID:18298671</ref> <ref>PMID:19955405</ref>
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[[http://www.uniprot.org/uniprot/P2C56_ARATH P2C56_ARATH]] Key component and repressor of the abscisic acid (ABA) signaling pathway that regulates numerous ABA responses, such as stomatal closure, osmotic water permeability of the plasma membrane (Pos), drought-induced resistance and rhizogenesis, response to glucose, high light stress, seed germination and inhibition of vegetative growth. During the stomatal closure regulation, modulates the inward calcium-channel permeability as well as the actin reorganization in guard cells in response to ABA. Involved in the resistance to the bacterial pathogen Pseudomonas syringae pv. tomato. Controls negatively fibrillin expression that is involved in mediating ABA-induced photoprotection. May be involved in ABA content regulation. Plays a role in the Pro accumulation in response to reduced water availability (low water potential). Required for the ABA negative regulation of the ethylene-induced hyponastic growth. Involved in acquired thermotolerance of root growth and seedling survival. Activates/represses SRK2E/OST1 in response to ABA-dependent stimuli, especially in stomata closure regulation involving SLAC1.<ref>PMID:12228349</ref> <ref>PMID:1834244</ref> <ref>PMID:16652949</ref> <ref>PMID:8492808</ref> <ref>PMID:12232276</ref> <ref>PMID:12232124</ref> <ref>PMID:7568166</ref> <ref>PMID:12228349</ref> <ref>PMID:8898906</ref> <ref>PMID:8771791</ref> <ref>PMID:9108297</ref> <ref>PMID:9090884</ref> <ref>PMID:9165752</ref> <ref>PMID:9161030</ref> <ref>PMID:9263461</ref> <ref>PMID:9351242</ref> <ref>PMID:9276963</ref> <ref>PMID:9448270</ref> <ref>PMID:10645425</ref> <ref>PMID:10488243</ref> <ref>PMID:10521520</ref> <ref>PMID:10950871</ref> <ref>PMID:10872217</ref> <ref>PMID:11707572</ref> <ref>PMID:11208021</ref> <ref>PMID:11587514</ref> <ref>PMID:11289613</ref> <ref>PMID:11701885</ref> <ref>PMID:12194854</ref> <ref>PMID:12065416</ref> <ref>PMID:12432076</ref> <ref>PMID:12047634</ref> <ref>PMID:12713537</ref> <ref>PMID:14576281</ref> <ref>PMID:14596925</ref> <ref>PMID:12609042</ref> <ref>PMID:15144382</ref> <ref>PMID:15197253</ref> <ref>PMID:15618419</ref> <ref>PMID:15923322</ref> <ref>PMID:16365038</ref> <ref>PMID:16339784</ref> <ref>PMID:16571665</ref> <ref>PMID:16798945</ref> <ref>PMID:16614222</ref> <ref>PMID:17304219</ref> <ref>PMID:17158582</ref> <ref>PMID:18298671</ref> <ref>PMID:19955405</ref> [[http://www.uniprot.org/uniprot/PYL1_ARATH PYL1_ARATH]] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA.<ref>PMID:19407143</ref> <ref>PMID:19898420</ref> <ref>PMID:19855379</ref> <ref>PMID:19893533</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jrq ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3jrq" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Arath]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Kubota, K]]
[[Category: Kubota, K]]

Revision as of 08:31, 9 February 2016

Crystal structure of (+)-ABA-bound PYL1 in complex with ABI1

3jrq, resolution 2.10Å

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