1evo
From Proteopedia
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|PDB= 1evo |SIZE=350|CAPTION= <scene name='initialview01'>1evo</scene> | |PDB= 1evo |SIZE=350|CAPTION= <scene name='initialview01'>1evo</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1evo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1evo OCA], [http://www.ebi.ac.uk/pdbsum/1evo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1evo RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Hosur, R V.]] | [[Category: Hosur, R V.]] | ||
[[Category: Patel, P K.]] | [[Category: Patel, P K.]] | ||
| - | [[Category: | + | [[Category: c-tetrad]] |
| + | [[Category: g-quadruplex]] | ||
| + | [[Category: gggcgg repeat]] | ||
| + | [[Category: nmr structure]] | ||
[[Category: sv40]] | [[Category: sv40]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:10:30 2008'' |
Revision as of 17:10, 30 March 2008
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| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR OBSERVATION OF A NOVEL C-TETRAD
Overview
We report the NMR structure of the DNA sequence d-TGGGCGGT in Na(+) solutions at neutral pH, containing a repeat sequence from SV40 viral genome. The structure is a novel quadruplex incorporating the C-tetrad formed by symmetrical pairing of four Cs via NH(2)&bond;O(2) H-bonds in a plane. The C-tetrad has a wider cavity compared to G-tetrads and stacks well over the adjacent G4-tetrad, but poorly on the G6 tetrad. The quadruplex helix is largely underwound by 8-10 degrees compared to B-DNA except at the C5-G6 step. To our knowledge this is the first report of C-tetrad formation in DNA structures, and would be of significance from the point of view of both structural diversity and specific recognition.
About this Structure
1EVO is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
NMR observation of a novel C-tetrad in the structure of the SV40 repeat sequence GGGCGG., Patel PK, Bhavesh NS, Hosur RV, Biochem Biophys Res Commun. 2000 Apr 21;270(3):967-71. PMID:10772934
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