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Ephrin receptor

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[[Image:3hei.png|left|200px|thumb|Crystal Structure of ephrin A2 receptor complex with ephrin, [[3hei]]]]
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<StructureSection load='3fxx' size='350' side='right' scene='' caption='Human ephrin A3 receptor (grey) complex with peptide substrate (green), nucleotide derivative (stick model) and Mg+2 ion [[3fxx]]'>
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{{STRUCTURE_3fxx| PDB=3fxx | SIZE=300| SCENE= |right|CAPTION=Human ephrin A3 receptor (grey) complex with peptide substrate (green), nucleotide derivative (stick model) and Mg+2 ion [[3fxx]] }}
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== Function ==
== Function ==
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EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972).
EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972).
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</StructureSection>
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== 3D Structures of ephrin receptors ==
== 3D Structures of ephrin receptors ==

Revision as of 13:39, 9 February 2016

Human ephrin A3 receptor (grey) complex with peptide substrate (green), nucleotide derivative (stick model) and Mg+2 ion 3fxx

Drag the structure with the mouse to rotate

3D Structures of ephrin receptors

Updated on 09-February-2016


References

  1. Pitulescu ME, Adams RH. Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev. 2010 Nov 15;24(22):2480-92. doi: 10.1101/gad.1973910. PMID:21078817 doi:http://dx.doi.org/10.1101/gad.1973910
  2. Genander M, Frisen J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010 Oct;22(5):611-6. doi: 10.1016/j.ceb.2010.08.005. PMID:20810264 doi:http://dx.doi.org/10.1016/j.ceb.2010.08.005

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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