1f3m
From Proteopedia
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|PDB= 1f3m |SIZE=350|CAPTION= <scene name='initialview01'>1f3m</scene>, resolution 2.3Å | |PDB= 1f3m |SIZE=350|CAPTION= <scene name='initialview01'>1f3m</scene>, resolution 2.3Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=IOD:IODIDE ION'>IOD</scene> | + | |LIGAND= <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1f3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1f3m OCA], [http://www.ebi.ac.uk/pdbsum/1f3m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1f3m RCSB]</span> | ||
}} | }} | ||
| Line 29: | Line 32: | ||
[[Category: Meng, W.]] | [[Category: Meng, W.]] | ||
[[Category: Parrini, M-C.]] | [[Category: Parrini, M-C.]] | ||
| - | [[Category: IOD]] | ||
[[Category: autoinhibitory fragment]] | [[Category: autoinhibitory fragment]] | ||
[[Category: homodimer]] | [[Category: homodimer]] | ||
[[Category: kinase domain]] | [[Category: kinase domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:15:07 2008'' |
Revision as of 17:15, 30 March 2008
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| , resolution 2.3Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
Overview
The p21-activated kinases (PAKs), stimulated by binding with GTP-liganded forms of Cdc42 or Rac, modulate cytoskeletal actin assembly and activate MAP-kinase pathways. The 2.3 A resolution crystal structure of a complex between the N-terminal autoregulatory fragment and the C-terminal kinase domain of PAK1 shows that GTPase binding will trigger a series of conformational changes, beginning with disruption of a PAK1 dimer and ending with rearrangement of the kinase active site into a catalytically competent state. An inhibitory switch (IS) domain, which overlaps the GTPase binding region of PAK1, positions a polypeptide segment across the kinase cleft. GTPase binding will refold part of the IS domain and unfold the rest. A related switch has been seen in the Wiskott-Aldrich syndrome protein (WASP).
About this Structure
1F3M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch., Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC, Cell. 2000 Aug 4;102(3):387-97. PMID:10975528
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