1fat
From Proteopedia
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|PDB= 1fat |SIZE=350|CAPTION= <scene name='initialview01'>1fat</scene>, resolution 2.8Å | |PDB= 1fat |SIZE=350|CAPTION= <scene name='initialview01'>1fat</scene>, resolution 2.8Å | ||
|SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+In+Chain+A'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Binding+Site+In+Chain+B'>CAB</scene>, <scene name='pdbsite=CAC:Ca+Binding+Site+In+Chain+C'>CAC</scene>, <scene name='pdbsite=CAD:Ca+Binding+Site+In+Chain+D'>CAD</scene>, <scene name='pdbsite=MNA:Mn+Binding+Site+In+Chain+A'>MNA</scene>, <scene name='pdbsite=MNB:Mn+Binding+Site+In+Chain+B'>MNB</scene>, <scene name='pdbsite=MNC:Mn+Binding+Site+In+Chain+C'>MNC</scene> and <scene name='pdbsite=MND:Mn+Binding+Site+In+Chain+D'>MND</scene> | |SITE= <scene name='pdbsite=CAA:Ca+Binding+Site+In+Chain+A'>CAA</scene>, <scene name='pdbsite=CAB:Ca+Binding+Site+In+Chain+B'>CAB</scene>, <scene name='pdbsite=CAC:Ca+Binding+Site+In+Chain+C'>CAC</scene>, <scene name='pdbsite=CAD:Ca+Binding+Site+In+Chain+D'>CAD</scene>, <scene name='pdbsite=MNA:Mn+Binding+Site+In+Chain+A'>MNA</scene>, <scene name='pdbsite=MNB:Mn+Binding+Site+In+Chain+B'>MNB</scene>, <scene name='pdbsite=MNC:Mn+Binding+Site+In+Chain+C'>MNC</scene> and <scene name='pdbsite=MND:Mn+Binding+Site+In+Chain+D'>MND</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fat OCA], [http://www.ebi.ac.uk/pdbsum/1fat PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fat RCSB]</span> | ||
}} | }} | ||
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[[Category: Hamelryck, T.]] | [[Category: Hamelryck, T.]] | ||
[[Category: Loris, R.]] | [[Category: Loris, R.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: MN]] | ||
| - | [[Category: NAG]] | ||
[[Category: glycoprotein]] | [[Category: glycoprotein]] | ||
[[Category: lectin]] | [[Category: lectin]] | ||
[[Category: plant defense protein]] | [[Category: plant defense protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:19:19 2008'' |
Revision as of 17:19, 30 March 2008
| |||||||
| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | , , , , , , and | ||||||
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PHYTOHEMAGGLUTININ-L
Overview
The structure of phytohemagglutinin-L (PHA-L), a leucoagglutinating seed lectin from Phaseolus vulgaris, has been solved with molecular replacement using the coordinates of lentil lectin as model, and refined at a resolution of 2.8 A. The final R-factor of the structure is 20.0%. The quaternary structure of the PHA-L tetramer differs from the structures of the concanavalin A and peanut lectin tetramers, but resembles the structure of the soybean agglutinin tetramer. PHA-L consists of two canonical legume lectin dimers that pack together through the formation of a close contact between two beta-strands. Of the two covalently bound oligosaccharides per monomer, only one GlcNAc residue per monomer is visible in the electron density. In this article we describe the structure of PHA-L, and we discuss the putative position of the high affinity adenine-binding site present in a number of legume lectins. A comparison with transthyretin, a protein that shows a remarkable resemblance to PHA-L, gives further ground to our proposal.
About this Structure
1FAT is a Single protein structure of sequence from Phaseolus vulgaris. Full crystallographic information is available from OCA.
Reference
The crystallographic structure of phytohemagglutinin-L., Hamelryck TW, Dao-Thi MH, Poortmans F, Chrispeels MJ, Wyns L, Loris R, J Biol Chem. 1996 Aug 23;271(34):20479-85. PMID:8702788
Page seeded by OCA on Sun Mar 30 20:19:19 2008
