1ffx
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1ffx |SIZE=350|CAPTION= <scene name='initialview01'>1ffx</scene>, resolution 3.95Å | |PDB= 1ffx |SIZE=350|CAPTION= <scene name='initialview01'>1ffx</scene>, resolution 3.95Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ffx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ffx OCA], [http://www.ebi.ac.uk/pdbsum/1ffx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ffx RCSB]</span> | ||
}} | }} | ||
| Line 26: | Line 29: | ||
[[Category: Knossow, M.]] | [[Category: Knossow, M.]] | ||
[[Category: Martin-Barbey, C.]] | [[Category: Martin-Barbey, C.]] | ||
| - | [[Category: GDP]] | ||
| - | [[Category: GTP]] | ||
[[Category: alpha-tubulin]] | [[Category: alpha-tubulin]] | ||
[[Category: beta-tubulin]] | [[Category: beta-tubulin]] | ||
| Line 34: | Line 35: | ||
[[Category: tubulin]] | [[Category: tubulin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:22:13 2008'' |
Revision as of 17:22, 30 March 2008
| |||||||
| , resolution 3.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX
Overview
Phosphoproteins of the stathmin family interact with the alphabeta tubulin heterodimer (tubulin) and hence interfere with microtubule dynamics. The structure of the complex of GDP-tubulin with the stathmin-like domain of the neural protein RB3 reveals a head-to-tail assembly of two tubulins with a 91-residue RB3 alpha helix in which each copy of an internal duplicated sequence interacts with a different tubulin. As a result of the relative orientations adopted by tubulins and by their alpha and beta subunits, the tubulin:RB3 complex forms a curved structure. The RB3 helix thus most likely prevents incorporation of tubulin into microtubules by holding it in an assembly with a curvature very similar to that of the depolymerization products of microtubules.
About this Structure
1FFX is a Protein complex structure of sequences from Bos taurus and Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
The 4 A X-ray structure of a tubulin:stathmin-like domain complex., Gigant B, Curmi PA, Martin-Barbey C, Charbaut E, Lachkar S, Lebeau L, Siavoshian S, Sobel A, Knossow M, Cell. 2000 Sep 15;102(6):809-16. PMID:11030624
Page seeded by OCA on Sun Mar 30 20:22:13 2008
