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1fin
From Proteopedia
| Line 7: | Line 7: | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fin OCA], [http://www.ebi.ac.uk/pdbsum/1fin PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1fin RCSB]</span> | ||
}} | }} | ||
| Line 25: | Line 28: | ||
[[Category: Pavletich, N P.]] | [[Category: Pavletich, N P.]] | ||
[[Category: Russo, A A.]] | [[Category: Russo, A A.]] | ||
| - | [[Category: ATP]] | ||
[[Category: cdk]] | [[Category: cdk]] | ||
[[Category: complex (transferase/cyclin)]] | [[Category: complex (transferase/cyclin)]] | ||
| Line 31: | Line 33: | ||
[[Category: phosphorylation]] | [[Category: phosphorylation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:23:38 2008'' |
Revision as of 17:23, 30 March 2008
| |||||||
| , resolution 2.3Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CYCLIN A-CYCLIN-DEPENDENT KINASE 2 COMPLEX
Overview
The crystal structure of the human cyclinA-cyclin-dependent kinase2 (CDK2)-ATP complex has been determined at 2.3 A resolution. CyclinA binds to one side of CDK2's catalytic cleft, inducing large conformational changes in its PSTAIRE helix and T-loop. These changes activate the kinase by realigning active site residues and relieving the steric blockade at the entrance of the catalytic cleft.
About this Structure
1FIN is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex., Jeffrey PD, Russo AA, Polyak K, Gibbs E, Hurwitz J, Massague J, Pavletich NP, Nature. 1995 Jul 27;376(6538):313-20. PMID:7630397
Page seeded by OCA on Sun Mar 30 20:23:38 2008
