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1h9o

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==About this Structure==
==About this Structure==
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1H9O is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Structure known Active Site: PTR. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H9O OCA]].
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1H9O is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Structure known Active Site: PTR. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H9O OCA].
==Reference==
==Reference==
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[[Category: signal transduction]]
[[Category: signal transduction]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:33:03 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:25:09 2007''

Revision as of 13:19, 5 November 2007

Image:1h9o.gif

1h9o, resolution 1.79Å

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PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, CRYSTAL STRUCTURE AT 1.79 A

Overview

Two cases of successful molecular replacement using NMR trial models are, presented. One is the crystal structure of the Escherichia coli colicin, immunity protein Im7; the other is a heretofore unreported crystal, structure of a specific PDGF receptor-derived peptide complex of the, carboxy-terminal SH2 domain from the p85alpha subunit of human, phosphatidylinositol 3-OH kinase. In both cases, molecular replacement was, non-trivial. Success was achieved using trial models that consisted of an, ensemble of NMR structures from which the more flexible portions had been, excised. Use of maximum-likelihood refinement proved critical to be able, to refine the poor starting models. The challenges typical of the use of, NMR trial models in molecular replacement are discussed.

About this Structure

1H9O is a Protein complex structure of sequences from Homo sapiens. Structure known Active Site: PTR. Full crystallographic information is available from OCA.

Reference

NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex., Pauptit RA, Dennis CA, Derbyshire DJ, Breeze AL, Weston SA, Rowsell S, Murshudov GN, Acta Crystallogr D Biol Crystallogr. 2001 Oct;57(Pt 10):1397-404. Epub, 2001 Sep 21. PMID:11567151

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