Bromodomain-containing protein

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'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones.
'''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones.
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<ref>PMID:21638687</ref>
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For detalis on BRD3 see [[Human bromodomain containing protein 3]]
For detalis on BRD3 see [[Human bromodomain containing protein 3]]

Revision as of 09:44, 10 February 2016

Human bromodomain-containing protein 4 bromodomain 1 complex with inhibitor (PDB code 4bw2)

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3D Structures of bromodomain-containing protein

Updated on 10-February-2016


References

  1. Belkina AC, Denis GV. BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer. 2012 Jun 22;12(7):465-77. doi: 10.1038/nrc3256. PMID:22722403 doi:http://dx.doi.org/10.1038/nrc3256

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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