Bromodomain-containing protein
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
== Function == | == Function == | ||
| - | '''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones. | + | '''Bromodomain-containing proteins''' (BRD) are active as histone acetyltransferase, chromatin remodeling and transcriptional mediation. The bromodomain is a ca. 110 amino acid long sequence which recognizes acetylated lysine residues which are found in the C-terminal of histones<ref>PMID:11911891</ref>. |
For detalis on BRD3 see [[Human bromodomain containing protein 3]] | For detalis on BRD3 see [[Human bromodomain containing protein 3]] | ||
| Line 8: | Line 8: | ||
== Disease == | == Disease == | ||
| - | Dysfunction of BRD is involved in cancer, inflammation, obesity and multiple sclerosis<ref>PMID:22722403</ref>. | + | Dysfunction of BRD is involved in cancer, inflammation, obesity and multiple sclerosis<ref>PMID:22722403</ref>. BRD4 translocations are detected in NUT midline carcinoma and a variety of BRD4 inhibitors are clinically tested at the present<ref>PMID:18552174</ref>. |
| - | + | ||
| - | + | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:51, 10 February 2016
| |||||||||||
3D Structures of bromodomain-containing protein
Updated on 10-February-2016
References
- ↑ Zeng L, Zhou MM. Bromodomain: an acetyl-lysine binding domain. FEBS Lett. 2002 Feb 20;513(1):124-8. PMID:11911891
- ↑ Belkina AC, Denis GV. BET domain co-regulators in obesity, inflammation and cancer. Nat Rev Cancer. 2012 Jun 22;12(7):465-77. doi: 10.1038/nrc3256. PMID:22722403 doi:http://dx.doi.org/10.1038/nrc3256
- ↑ French CA. Demystified molecular pathology of NUT midline carcinomas. J Clin Pathol. 2010 Jun;63(6):492-6. doi: 10.1136/jcp.2007.052902. Epub 2008 Jun , 13. PMID:18552174 doi:http://dx.doi.org/10.1136/jcp.2007.052902
