4z9v

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'''Unreleased structure'''
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==TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL==
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<StructureSection load='4z9v' size='340' side='right' caption='[[4z9v]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4z9v]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z9V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z9V FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z9v OCA], [http://pdbe.org/4z9v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z9v RCSB], [http://www.ebi.ac.uk/pdbsum/4z9v PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> [[http://www.uniprot.org/uniprot/TCTP_HUMAN TCTP_HUMAN]] Involved in calcium binding and microtubule stabilization.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Translationally Controlled Tumor Protein (TCTP) is anti-apoptotic, key in development and cancer, however without the typical Bcl2 family members' structure. Here we report that TCTP contains a BH3-like domain and forms heterocomplexes with Bcl-xL. The crystal structure of a Bcl-xL deletion variant-TCTP11-31 complex reveals that TCTP refolds in a helical conformation upon binding the BH3-groove of Bcl-xL, although lacking the h1-subregion interaction. Experiments using in vitro-vivo reconstituted systems and TCTP(+/-) mice indicate that TCTP activates the anti-apoptotic function of Bcl-xL, in contrast to all other BH3-proteins. Replacing the non-conserved h1 of TCTP by that of Bax drastically increases the affinity of this hybrid for Bcl-xL, modifying its biological properties. This work reveals a novel class of BH3-proteins potentiating the anti-apoptotic function of Bcl-xL.
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The entry 4z9v is ON HOLD until Paper Publication
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TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.,Thebault S, Agez M, Chi X, Stojko J, Cura V, Telerman SB, Maillet L, Gautier F, Billas-Massobrio I, Birck C, Troffer-Charlier N, Karafin T, Honore J, Senff-Ribeiro A, Montessuit S, Johnson CM, Juin P, Cianferani S, Martinou JC, Andrews DW, Amson R, Telerman A, Cavarelli J Sci Rep. 2016 Jan 27;6:19725. doi: 10.1038/srep19725. PMID:26813996<ref>PMID:26813996</ref>
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Authors: Cura, V., Agez, M., Thebault, S., Cavarelli, J.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL
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<div class="pdbe-citations 4z9v" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Agez, M]]
[[Category: Cavarelli, J]]
[[Category: Cavarelli, J]]
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[[Category: Cura, V]]
[[Category: Thebault, S]]
[[Category: Thebault, S]]
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[[Category: Agez, M]]
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[[Category: Apoptose]]
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[[Category: Cura, V]]
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[[Category: Apoptosis]]
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[[Category: Bh3]]
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[[Category: Tctp]]

Revision as of 17:19, 10 February 2016

TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL

4z9v, resolution 2.10Å

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