5eg9

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m (Protected "5eg9" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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==The cap binding site of influenza virus protein PB2 as a drug target==
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<StructureSection load='5eg9' size='340' side='right' caption='[[5eg9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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The entry 5eg9 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5eg9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EG9 FirstGlance]. <br>
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Authors: Severin, C., Rocha de Moura, T., Liu, Y., Li, K., Zheng, X., Luo, M.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eg7|5eg7]], [[5eg8|5eg8]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eg9 OCA], [http://pdbe.org/5eg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eg9 RCSB], [http://www.ebi.ac.uk/pdbsum/5eg9 PDBsum]</span></td></tr>
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Description: The cap binding site of influenza virus protein PB2 as a drug target
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[http://www.uniprot.org/uniprot/PB2_I02A6 PB2_I02A6]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved after 10-13 nucleotides by PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex. In addition, participates in the inhibition of type I interferon induction through interaction with the host mitochondrial antiviral signaling protein MAVS.[UniProtKB:P03428]
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__TOC__
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</StructureSection>
[[Category: Li, K]]
[[Category: Li, K]]
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[[Category: Luo, M]]
 
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[[Category: Zheng, X]]
 
[[Category: Liu, Y]]
[[Category: Liu, Y]]
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[[Category: Luo, M]]
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[[Category: Moura, T Rocha de]]
[[Category: Severin, C]]
[[Category: Severin, C]]
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[[Category: Rocha De Moura, T]]
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[[Category: Zheng, X]]
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[[Category: Pb2 cap]]
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[[Category: Viral protein]]

Revision as of 17:27, 10 February 2016

The cap binding site of influenza virus protein PB2 as a drug target

5eg9, resolution 2.30Å

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