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Exportin
From Proteopedia
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'''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>. | '''Exportins''' (XPO) or '''chromosomal maintenance protein''' mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. '''XPO-t''' exports tRNA from the nucleus<ref>PMID:17786152</ref>. | ||
| - | <scene name='59/592125/Cv/2'> | + | ==Structural highlighta == |
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| + | <scene name='59/592125/Cv/2'>Yeast exportin-5 with GTPaseRan, Mg+2 and RNA</scene> (PDB code [[3icq]]). | ||
| + | |||
| + | <scene name='59/592125/Cv/6'>GTP binding site</scene> | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:18, 15 February 2016
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3D structures of exportin
Updated on 15-February-2016
References
- ↑ Kohler A, Hurt E. Exporting RNA from the nucleus to the cytoplasm. Nat Rev Mol Cell Biol. 2007 Oct;8(10):761-73. PMID:17786152 doi:http://dx.doi.org/10.1038/nrm2255
