PcrH

From Proteopedia

Revision as of 12:51, 15 February 2016

spinqualitylabelsall models PcrH (magenta, green) complex with PopD chaperone binding peptide (cyan) and NO3- ion (PDB code 2xcb) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function PcrH or Regulatory protein PcrH is a chaperone protein which is a member of the translocon system which enables bacteria to form a pore in the cell wall for the insertion of toxins into it. See details in Molecular Playground/Pcr H. Structural highlights PcrH contains a helical Tpr domain (tetratricopeptide) which interacts with the translocator PopD or PopB peptide[1]. PopD peptide binds at the concave surface of PcrH.

3D Structures of lactoferrin

Updated on 15-February-2016

2xcc - PaPcrH – Pseudomonas aeruginosa
2xcb - PaPcrH + PopD chaperone-binding peptide
4jl0 - PaPcrH + PopB chaperone-binding peptide

References

1. ↑ Job V, Mattei PJ, Lemaire D, Attree I, Dessen A. Structural basis of chaperone recognition of type III secretion system minor translocator proteins. J Biol Chem. 2010 Jul 23;285(30):23224-32. Epub 2010 Apr 12. PMID:20385547 doi:10.1074/jbc.M110.111278