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Ribonucleotide reductase

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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=400| SCENE= |right|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }}
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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=350| SCENE= |right|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }}
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.<br />
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.<br />
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* '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center.<br />
* '''Class III RNR''' generate glycine radical using S-adenosyl methionine and Fe-S center.<br />
For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].
For details on human RNR2 see [[P53R2]]. For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].
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== 3D Structures of Ribonucleotide reductase ==
== 3D Structures of Ribonucleotide reductase ==

Revision as of 07:58, 16 February 2016

Template:STRUCTURE 1xjf

Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.

  • Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.
  • Class II RNR reduces ribonucleotide triphosphates using coenzyme B12.
  • Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center.

For details on human RNR2 see P53R2. For mouse RNR see Mouse Ribonucleotide Reductase R2.

3D Structures of Ribonucleotide reductase

Updated on 16-February-2016

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