Nuclear transcription factor Y

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Revision as of 10:54, 16 February 2016

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spinqualitylabelsall models Caption for this structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Nuclear transcription factor Y (NFY) binds to a CCAAT sequence of gene promoters. NFY contains 3 subunits while subunit α binds the promoter box sequence[1]. See details in NF-Y Transcription Factor. Disease Relevance NFY is a regulatory factor for many genes which are overexpressed in many kinds of cancer. Structural highlights

3D Structures of nuclear transcription factor Y

Updated on 16-February-2016

1n1j, 4csr – hNFY β+γ subunits - human
4awl – hNFY α+β+γ subunits + promoter DNA

References

1. ↑ Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May;23(5):174-8. PMID:9612081