Factor VIII

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[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].
[[Factor VIII]] (FVIII) is a blood clotting factor. FVIII is a cofactor for [[Factor IX|factor IXa]]<ref>PMID:2491949</ref> . See also [[Factor VIII (Hebrew)]].
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<scene name='45/451726/Cv/3'>First Ca coordination site</scene>.
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===RECOMBINANT HUMAN CELLULAR COAGULATION FACTOR XIII===
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The A subunit is composed of an activation peptide and 4 domains: the β-sandwich <scene name='1f13/Chaina_domain1/1'>domain</scene>, the central core domain, the barrel 1 domain, and the
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<scene name='1f13/Fxiii_4domains_colored/1'>barrel 2 domain</scene>.-->
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== Disease ==
== Disease ==

Revision as of 12:53, 16 February 2016

Glycosylated human Factor VIII. Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e)

Drag the structure with the mouse to rotate

3D Structures of Factor VIII

Updated on 16-February-2016

2r7e, 3cdz, 3j2q, 4bdv – hFVIII – human
3hnb, 3hny, 3hob – hFVIII light chain C2 domain
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse
3j2s - hFVIII light chain
4mo3 - FVIII light chain C2 domain – pig

References

  1. ↑ White GC 2nd, Shoemaker CB. Factor VIII gene and hemophilia A. Blood. 1989 Jan;73(1):1-12. PMID:2491949

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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