Myoglobin
From Proteopedia
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| - | <StructureSection load='1a6m' size='350' side='right' caption='Structure of Sperm whale myoglobin with O2 and sulfate (PDB entry [[1a6m]])' scene=''> | + | <StructureSection load='1a6m' size='350' side='right' caption='Structure of Sperm whale myoglobin containing protoporphyrin with O2 and sulfate (PDB entry [[1a6m]])' scene=''> |
[[Myoglobin]] is a globular protein whose function is to store molecular oxygen in muscles (myo = muscles). It has two main components: a single polypeptide chain, and heme ligand. The heme ligand is only <scene name='23/238129/Transparent_spacefill/2'>partially exposed</scene> to the surface; the majority of it is buried inside the protein. The overall <scene name='23/238129/Surface/1'>shape</scene> of myoglobin is approximately disc-shaped with a diameter that is about twice its thickness. The overall fold of the protein is conserved, especially the <scene name='23/238129/Hydrophobic/1'>hydrophobic</scene> core of the protein (shown in purple), but the sequence is more <scene name='23/238129/Conserved_cartoon/1'>variable</scene> on the surface. {{Template:ColorKey_ConSurf_NoYellow_NoGray}} | [[Myoglobin]] is a globular protein whose function is to store molecular oxygen in muscles (myo = muscles). It has two main components: a single polypeptide chain, and heme ligand. The heme ligand is only <scene name='23/238129/Transparent_spacefill/2'>partially exposed</scene> to the surface; the majority of it is buried inside the protein. The overall <scene name='23/238129/Surface/1'>shape</scene> of myoglobin is approximately disc-shaped with a diameter that is about twice its thickness. The overall fold of the protein is conserved, especially the <scene name='23/238129/Hydrophobic/1'>hydrophobic</scene> core of the protein (shown in purple), but the sequence is more <scene name='23/238129/Conserved_cartoon/1'>variable</scene> on the surface. {{Template:ColorKey_ConSurf_NoYellow_NoGray}} | ||
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The <scene name='23/238129/Heme/3'>heme ligand</scene>, and specifically the iron atom in the middle of the heme, is what binds oxygen in myoglobin. In this representation, the heme alone is shown in ball and stick form with its C, N and O atoms displayed as grey, blue, and red balls respectively. The iron atom is shown in orange, and is in spacefill to better illustrate its interactions with the heme. The iron is bound by four nitrogen atoms found in the heme ring, as well as an <scene name='23/238129/Fe_ligands/1'>amino acid</scene> from the protein chain. Which amino acid from the myoglobin protein binds to the iron? Notice that in the oxygenated state, the iron is in the plane of the heme ring. In the <scene name='23/238129/Deoxy_heme_fe_plane/1'>deoxy</scene> (no oxygen) state, the Fe atom is slightly above the plane of the heme, and a second <scene name='23/238129/Deoxy_heme_his/1'>amino acid</scene> coordinates with the iron in the heme ring. | The <scene name='23/238129/Heme/3'>heme ligand</scene>, and specifically the iron atom in the middle of the heme, is what binds oxygen in myoglobin. In this representation, the heme alone is shown in ball and stick form with its C, N and O atoms displayed as grey, blue, and red balls respectively. The iron atom is shown in orange, and is in spacefill to better illustrate its interactions with the heme. The iron is bound by four nitrogen atoms found in the heme ring, as well as an <scene name='23/238129/Fe_ligands/1'>amino acid</scene> from the protein chain. Which amino acid from the myoglobin protein binds to the iron? Notice that in the oxygenated state, the iron is in the plane of the heme ring. In the <scene name='23/238129/Deoxy_heme_fe_plane/1'>deoxy</scene> (no oxygen) state, the Fe atom is slightly above the plane of the heme, and a second <scene name='23/238129/Deoxy_heme_his/1'>amino acid</scene> coordinates with the iron in the heme ring. | ||
| - | For myoglobin complex with O2 see [[Oxymyoglobin]]. | + | For myoglobin complex with O2 see [[Oxymyoglobin]]<br /> |
| + | For porphyrin see [[Porphyrin]]. | ||
See also [[Molecular Playground/Myoglobin]], [[Extremophile]] and [[Extremophiles]]. | See also [[Molecular Playground/Myoglobin]], [[Extremophile]] and [[Extremophiles]]. | ||
Revision as of 08:58, 18 February 2016
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3D Structures of Myoglobin
Updated on 18-February-2016 Myoglobin (Mb) is an oxygen binding protein found in muscle tissue. It contains a heme group. Metmyoglobin (MMb) is the oxidized form of myoglobin.
((3qm5, 3qm6 – btMb – blackfin tuna
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Michal Harel, Ann Taylor, Alexander Berchansky, Joel L. Sussman, Eric Martz, Jaime Prilusky, Karsten Theis, Karl Oberholser, Eran Hodis, Judy Voet, David Canner
