4ove
From Proteopedia
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==X-ray Crystal Structure of Mouse Netrin-1== | ==X-ray Crystal Structure of Mouse Netrin-1== | ||
<StructureSection load='4ove' size='340' side='right' caption='[[4ove]], [[Resolution|resolution]] 2.64Å' scene=''> | <StructureSection load='4ove' size='340' side='right' caption='[[4ove]], [[Resolution|resolution]] 2.64Å' scene=''> | ||
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<table><tr><td colspan='2'>[[4ove]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVE FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ove]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVE FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ove FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ove OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ove RCSB], [http://www.ebi.ac.uk/pdbsum/4ove PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ove FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ove OCA], [http://pdbe.org/4ove PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ove RCSB], [http://www.ebi.ac.uk/pdbsum/4ove PDBsum]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/NET1_MOUSE NET1_MOUSE]] Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). | [[http://www.uniprot.org/uniprot/NET1_MOUSE NET1_MOUSE]] Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism to allow these tumors to escape the pro-apoptotic activity of some of its main dependence receptors, the UNC5 homologs (UNC5H). Here we identify the V-2 domain of netrin-1 to be important for its interaction with the Ig1/Ig2 domains of UNC5H2. We generate a humanized anti-netrin-1 antibody that disrupts the interaction between netrin-1 and UNC5H2 and triggers death of netrin-1-expressing tumor cells in vitro. We also present evidence that combining the anti-netrin-1 antibody with epidrugs such as decitabine could be effective in treating tumors showing no or modest netrin-1 expression. These results support that this antibody is a promising drug candidate. | ||
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| + | Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers.,Grandin M, Meier M, Delcros JG, Nikodemus D, Reuten R, Patel TR, Goldschneider D, Orriss G, Krahn N, Boussouar A, Abes R, Dean Y, Neves D, Bernet A, Depil S, Schneiders F, Poole K, Dante R, Koch M, Mehlen P, Stetefeld J Cancer Cell. 2016 Feb 8;29(2):173-85. doi: 10.1016/j.ccell.2016.01.001. PMID:26859457<ref>PMID:26859457</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4ove" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[Netrin|Netrin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:07, 20 February 2016
X-ray Crystal Structure of Mouse Netrin-1
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Categories: Koch, M | Meier, M | Nikodemus, D | Okun, N | Orriss, G | Patel, T R | Reuten, R | Stetefeld, J | Apoptosis | Axon guidance cue | Dcc | Domain vi: beta-sandwich jelly-roll | Domains v-1 | Dscam | Extracellular matrix | Neogenin | Similar to laminin gamma-1 | Structural calcium | Survival factor | Unc5a | Unc5b | Unc5c | Unc5d | V-2 | V-3: laminin-type epidermal growth factor
