5cz2
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a two-domain fragment of MMTV integrase== | |
| - | + | <StructureSection load='5cz2' size='340' side='right' caption='[[5cz2]], [[Resolution|resolution]] 2.72Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cz2]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZ2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cz2 OCA], [http://pdbe.org/5cz2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cz2 RCSB], [http://www.ebi.ac.uk/pdbsum/5cz2 PDBsum]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POL_MMTVB POL_MMTVB]] During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ballandras-Colas, A]] | [[Category: Ballandras-Colas, A]] | ||
| + | [[Category: Cherepanov, P]] | ||
[[Category: Cook, N]] | [[Category: Cook, N]] | ||
[[Category: Engelman, A]] | [[Category: Engelman, A]] | ||
| - | [[Category: | + | [[Category: Amino terminal domain]] |
| + | [[Category: Catalytic core domain]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Integrase]] | ||
| + | [[Category: Pol]] | ||
| + | [[Category: Retrovirus]] | ||
| + | [[Category: Zinc binding]] | ||
Revision as of 02:53, 21 February 2016
Crystal structure of a two-domain fragment of MMTV integrase
| |||||||||||
