We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

Bone morphogenetic protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(Removing all content from page)
Line 1: Line 1:
 +
<StructureSection load='2qja' size='350' side='right' caption='Human α-defensin 1 (PDB entry [[2pm4]])' scene=''>
 +
__TOC__
 +
== Function ==
 +
 +
'''Bone morphogenetic protein''' (BMP) are growth factors which can induce formation of bone and cartllage'<ref>PMID:19900831</ref>. Over 20 BMPs are known at present. BMP is part of the Transforming Growth Factor-β (TGF-β) family of proteins. For details on BMP-2 see [[Student Projects for UMass Chemistry 423 Spring 2014-4]].
 +
== Relevance ==
 +
 +
Recombinant BMP is used in oral surgery and spinal fusion.
 +
 +
== Disease ==
 +
 +
BMP-7 is involved in chronic kidney disease<ref>PMID:18508541</ref>.
 +
 +
== Structural highlights ==
 +
 +
 +
</StructureSection>
 +
==3D structures of bone morphogenetic protein==
 +
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
 +
 +
*Bone morphogenetic protein 1
 +
 +
**[[3edg]], [[3edh]] – hBMP protease domain – human<br />
 +
 +
*Bone morphogenetic protein 2
 +
 +
**[[3bmp]] – hBMP <br />
 +
**[[1reu]] – hBMP (mutant)<br />
 +
**[[4n1d]] – hBMP/Nodal <br />
 +
**[[4mid]] – hBMP/activin A <br />
 +
**[[1es7]], [[1rew]], [[2qj9]], [[2qja]], [[2qjb]] – hBMP + BMP receptor IA<br />
 +
**[[3bk3]] – hBMP + crossveinless 2<br />
 +
**[[2goo]], [[2h62]], [[2h64]] – hBMP + BMP receptor IA + activin II receptor <br />
 +
**[[4uhy]], [[4uhz]], [[4ui0]], [[4ui1]] – hBMP C terminal + repulsive guidance molecule<br />
 +
**[[4ui2]] – hBMP C terminal + repulsive guidance molecule + neogenin<br />
 +
 +
*Bone morphogenetic protein 3
 +
 +
**[[2qcq]] – hBMP <br />
 +
 +
*Bone morphogenetic protein 6
 +
 +
**[[2qcw]], [[2r52]], [[2r53]] – hBMP <br />
 +
 +
*Bone morphogenetic protein 7
 +
 +
**[[1bmp]], [[1lxi]] – hBMP <br />
 +
**[[1m4u]] – hBMP + noggin<br />
 +
**[[1lx5]] – hBMP + activin II receptor<br />
 +
 +
*Bone morphogenetic protein 9
 +
 +
**[[1zkz]], [[4mpl]] – hBMP <br />
 +
**[[4ycg]], [[4yci]] – BMP - mouse<br />
 +
 +
}}
 +
== References ==
 +
<references/>
 +
[[Category:Topic Page]]

Revision as of 12:08, 22 February 2016

Human α-defensin 1 (PDB entry 2pm4)

Drag the structure with the mouse to rotate

3D structures of bone morphogenetic protein

Updated on 22-February-2016

References

  1. ↑ Reddi AH, Reddi A. Bone morphogenetic proteins (BMPs): from morphogens to metabologens. Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):341-2. doi:, 10.1016/j.cytogfr.2009.10.015. Epub 2009 Nov 8. PMID:19900831 doi:http://dx.doi.org/10.1016/j.cytogfr.2009.10.015
  2. ↑ Mitu G, Hirschberg R. Bone morphogenetic protein-7 (BMP7) in chronic kidney disease. Front Biosci. 2008 May 1;13:4726-39. PMID:18508541

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Bone_morphogenetic_protein"
Personal tools