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	<Structure load='1db1' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='Insert optional scene name here' />		<Structure load='1db1' size='300' frame='true' align='right' caption='pdbcode, Insert caption here' scene='Insert optional scene name here' />
	<br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>		<br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br>
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		+	Outline:
		+	-Discuss mutations in Vitamin D receptor (Rickets)
		+	-Regulating hair cycle
		+	-Examine attempts to regulate Vitamin D receptor
	==Quiz Question 1==		==Quiz Question 1==

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Revision as of 22:24, 23 February 2016

This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439.

Contents 1 Vitamin D receptor/vitamin D (1db1) 2 Introduction 3 Overall Structure 4 Binding Interactions 5 Additional Features 6 Quiz Question 1 7 See Also 8 Credits 9 References

Vitamin D receptor/vitamin D (1db1)

by Roger Crocker, Kate Daborowski, Patrick Murphy, Benjamin Rizkin and Aaron Thole

Student Projects for UMass Chemistry 423 Spring 2016

Introduction

spinqualitylabelsall models pdbcode 1db1, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

This is a sample scene created with SAT to by Group, and another to make of the protein.

Overall Structure

spinqualitylabelsall models pdbcode 1db1, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Binding Interactions

spinqualitylabelsall models pdbcode, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Protein 1db1 is found to complex with 1,25 Dihydroxy . This molecule has three notable alcohol groups that have the ability to participate in interactions with the protein. Vitamin D3 has a large number of relations with the residues on the protein chain. First in the sequence are . Tyr143, shown in blue, is the closest to the ligand at 2.83 angstroms. This is sightly large but there is still the possibility of hydrogen bonding. Tyr147 in green and Phe150 in black are also known to have interactions with Vitamin D3 they are farther away and therefore less significant.

Additional Features

spinqualitylabelsall models pdbcode, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Outline: -Discuss mutations in Vitamin D receptor (Rickets) -Regulating hair cycle -Examine attempts to regulate Vitamin D receptor

Quiz Question 1

spinqualitylabelsall models pdbcode, Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

See Also

• 3w0a
• 3w0c
• 3w0y
• 3w5t
• 3w5r
• 1db1

Credits

Introduction - Kate Daborowski

Overall Structure - Aaron Thole and Benjamin Rizkin

Drug Binding Site - Roger Crocker

Additional Features - Patrick Murphy

Quiz Question 1 - name of team member

References