2n8r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Productive complex between MMP-12 and synthetic triple-helical collagen, revealed through paramagnetic NMR== | |
| - | + | <StructureSection load='2n8r' size='340' side='right' caption='[[2n8r]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n8r]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N8R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N8R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2poj|2poj]]</td></tr> |
| - | [[Category: Prior, S | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n8r OCA], [http://pdbe.org/2n8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n8r RCSB], [http://www.ebi.ac.uk/pdbsum/2n8r PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Macrophage elastase]] | ||
| + | [[Category: Doren, S R.Van]] | ||
| + | [[Category: Prior, S H]] | ||
| + | [[Category: Collagenolysis]] | ||
| + | [[Category: Hydrolase-structural protein complex]] | ||
| + | [[Category: Matrix petalloproteinase]] | ||
Revision as of 18:06, 26 February 2016
Productive complex between MMP-12 and synthetic triple-helical collagen, revealed through paramagnetic NMR
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